| Friday, October 8th, 1965 | Activated SP Juan Nava from the disabled list. | Wednesday, October 6th, 1965 | MR José Vargas was designated for assignment, placed on waivers and taken off the 40-man roster. | Friday, October 1st, 1965 | Activated MR Vicente Santos from the disabled list. | Thursday, September 16th, 1965 | Placed SP Juan Nava on the 13-day disabled list. | Wednesday, September 8th, 1965 | Activated 1B Eduardo Rosas from the disabled list. | Tuesday, September 7th, 1965 | Placed MR Vicente Santos on the 13-day disabled list. | Wednesday, August 11th, 1965 | Signed Lynn Hopkins to a minor league contract with a signing bonus of $25,600. | Sunday, August 8th, 1965 | Signed Manny Hernández to a minor league contract with a signing bonus of $12,200. | Saturday, August 7th, 1965 | Signed Patrick Hodge to a minor league contract with a signing bonus of $46,000. | Thursday, July 29th, 1965 | Signed Juan García to a minor league contract with a signing bonus of $102,600. | Thursday, July 8th, 1965 | Signed Arthur Osborne to a minor league contract with a signing bonus of $7,200. | Sunday, June 27th, 1965 | Signed Alejandro Córdova to a minor league contract with a signing bonus of $10,800. | Sunday, May 16th, 1965 | Purchased the contract of SS Michael Hicks from Triple A Timmins. | RF Jesse Raines was designated for assignment and placed on waivers (from active). | Sunday, March 21st, 1965 | Placed RF Eric Thompson on the 13-day disabled list. | Monday, February 15th, 1965 | Activated SP Steven Embling from the 60-day disabled list. | SP Michael Carter was designated for assignment, placed on waivers and taken off the 40-man roster. | |
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