| Tuesday, September 28th, 1965 | Placed SS Chuck Williams on the 60-day disabled list. | Saturday, September 25th, 1965 | Activated 2B Byron Achber from the disabled list. | Saturday, September 11th, 1965 | Placed 1B Jesús Sánchez on the 13-day disabled list. | Tuesday, September 7th, 1965 | Activated SS Lee Parkinson from the disabled list. | Friday, August 6th, 1965 | Signed 1st round draft pick Herman Smith for a signing bonus of $53,300 and a 2-year major league contract worth a total of $106,600. | Tuesday, July 27th, 1965 | Signed Jason Duncan to a minor league contract with a signing bonus of $7,000. | Sunday, July 25th, 1965 | Signed Tim Potter to a minor league contract with a signing bonus of $13,700. | Thursday, July 22nd, 1965 | Signed Brad Flory to a minor league contract with a signing bonus of $18,700. | Thursday, July 1st, 1965 | Signed Paul Helton to a minor league contract with a signing bonus of $7,000. | Tuesday, June 8th, 1965 | Purchased the contract of SP Jeffrey Thomas from Double A Beeville. | MR Jason Lane was designated for assignment, placed on waivers and taken off the 40-man roster. | Thursday, November 19th, 1964 | Activated SP Jason Lane from the 60-day disabled list. | MR José Martínez was designated for assignment, placed on waivers and taken off the 40-man roster. | Monday, October 26th, 1964 | Signed general manager Dana Wallace to a 5-year, $33,400 per year contract. | |
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