| Friday, September 17th, 1965 | Activated RF Roger Mullins from the disabled list. | Thursday, September 9th, 1965 | Activated 2B Jorge Gonzáles from the disabled list. | Monday, September 6th, 1965 | Activated SS Gene Roberson from the 60-day disabled list. | RF José Gonzáles was designated for assignment, placed on waivers and taken off the 40-man roster. | Friday, August 20th, 1965 | Placed C Chris Ward on waivers. | Thursday, August 12th, 1965 | Signed José Sánchez to a minor league contract with a signing bonus of $54,700. | Signed Dan Edwards to a minor league contract with a signing bonus of $6,200. | Wednesday, June 30th, 1965 | Signed Garland Fisher to a minor league contract with a signing bonus of $10,900. | Sunday, June 20th, 1965 | Placed SS Gene Roberson on the 60-day disabled list. | Wednesday, March 31st, 1965 | Placed MR Pedro Pérez on the 13-day disabled list. | Sunday, March 28th, 1965 | Placed SS Jorge Gonzáles on the 13-day disabled list. | |
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