| Thursday, April 9th, 1981 |
| Promoted SP Vasco Galindo to Double A Alice. |
| Promoted SP António Navarro to Double A Alice. |
| Promoted MR Charlie Good to Double A Alice. |
| Promoted C Patrick Simmons to Double A Alice. |
| Promoted 3B Carlos Márquez to Double A Alice. |
| Promoted CF Bob Smith to Double A Alice. |
| Promoted 3B Mike Bradley to Double A Alice. |
| Promoted 1B Bob Jones to Double A Alice. |
| Promoted 1B Andy Scott to Double A Alice. |
| Promoted LF Cristián Rodríguez to Double A Alice. |
| Promoted LF Ed Hughes to Double A Alice. |
| Promoted MR Félix Moreno to Double A Alice. |
| Signed free agent C John O'Toole to a minor league contract. |
| Signed free agent C Javier Martínez to a minor league contract. |
| Signed free agent 3B Ken Hamilton to a minor league contract. |
| Signed free agent 2B Ernesto Delgado to a minor league contract. |
| Signed free agent RF Jesse O'Connor to a minor league contract. |
| Signed free agent CF Vernon Pye to a minor league contract. |
| Signed free agent LF Jim Bennett to a minor league contract. |
| Signed free agent 1B Rafael Adame to a minor league contract. |
| Signed free agent 2B Jeff James to a minor league contract. |
| Signed free agent RF Sterling MacLean to a minor league contract. |
| Signed free agent CF Ted Murphy to a minor league contract. |
| Promoted CF Ted Murphy to Triple A Keswick. |
| Promoted CL Alfredo Flores to Double A Alice. |
| Promoted 2B Jeff James to Double A Alice. |
| Promoted CF Vernon Pye to Double A Alice. |
| Promoted LF Jim Bennett to Double A Alice. |
| Promoted 1B Rafael Adame to Double A Alice. |
| Received MR Dave Palmer from Double A Alice. |
| Received 3B Carlos Márquez from Double A Alice. |
| Received 3B Mike Bradley from Double A Alice. |
| Received 1B Domingo Marín from Double A Alice. |
| Received RF Ed Hughes from Double A Alice. |
| Received SP Charles Lang from Double A Alice. |
