| Monday, September 22nd, 1980 |
| Received MR Ippei Gato from Double A Edna. |
| Received CL Júlio Longoria from Double A Edna. |
| Received MR Anthony Simms from Double A Edna. |
| Received 2B Tony Gamboa from Double A Edna. |
| Received LF R.J. Stewart from Double A Edna. |
| Received 1B Luke Weston from Double A Edna. |
| Received CF Joe Rodgers from Double A Edna. |
| Received 3B Dave Sexton from Double A Edna. |
| Demoted RF Mike Clark to Double A Edna. |
| Received MR Arturo Colón from Major League Level Boston. |
| Received MR Albert Maestas from Major League Level Boston. |
| Received C Morton Cotton from Major League Level Boston. |
| Received C Esteban Fríaz from Major League Level Boston. |
| Received 1B Rob Clay from Major League Level Boston. |
| Received 1B Stan Kelly from Major League Level Boston. |
| Received 2B Garland Higgins from Major League Level Boston. |
| Received 3B Pablo Mateo from Major League Level Boston. |
| Received RF Wayne Arthur from Major League Level Boston. |
| Received RF Manny Adkins from Major League Level Boston. |
| Received 2B Charlie Jordan from Major League Level Boston. |
| Received 1B Robert Nelson from Major League Level Boston. |
| Received 1B Xiong Tsou from Major League Level Boston. |
| Demoted SP Dani Muñóz to Double A Edna. |
| Demoted MR Anthony Simms to Double A Edna. |
| Demoted C Ron Alston to Double A Edna. |
| Demoted C Carl Dempsey to Double A Edna. |
| Demoted SS William Fisher to Double A Edna. |
| Demoted 2B Jorge Salas to Double A Edna. |
| Demoted LF Joe Rodgers to Double A Edna. |
| Demoted 1B Luke Weston to Double A Edna. |
| Demoted 3B Andrés Estrada to Double A Edna. |
| Demoted 1B Hal Kirby to Double A Edna. |
| Demoted 2B Tony Gamboa to Double A Edna. |
| Demoted LF R.J. Stewart to Double A Edna. |
| Demoted 3B Dave Sexton to Single A Whittier. |
