| Friday, April 17th, 1981 | Placed RF Guus Schumacher on the Southern California League 15-day disabled list. | Monday, April 13th, 1981 | Placed RF Arturo Taváres on the South Texas League 15-day disabled list. | Tuesday, April 7th, 1981 | Activated 2B Dave Day from the disabled list. | Thursday, April 2nd, 1981 | Placed MR Júlio Rodríguez on the 60-day disabled list. | Sunday, March 22nd, 1981 | Placed 2B Dave Day on the 9-day disabled list. | Friday, March 20th, 1981 | Signed 2B José Seminario to a minor league contract. | Tuesday, February 10th, 1981 | Signed SP Pedro Vázquez to a minor league contract. | Sunday, February 1st, 1981 | Activated SP Will Clark from the 60-day disabled list. | MR Michael Mack was designated for assignment, placed on waivers and taken off the 40-man roster. | Demoted MR Júlio Rodríguez to Triple A Vaughan. | Monday, December 1st, 1980 | SP Marcos Aranda was placed on the 40-man roster. | Monday, November 3rd, 1980 | Released SP Danny Owens.(Career-ending injury) | Sunday, October 19th, 1980 | Signed bench coach Elard Bongers to a 5-year, $117,000 per year contract. | |
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