| | | Sunday, August 20th, 1978 | | Activated 1B Derrick Young from the disabled list. |
| Friday, August 11th, 1978 | | Activated SP Joe Kimball from the disabled list. |
| Wednesday, August 9th, 1978 | | Placed MR Sergio Álvarez on the 15-day disabled list. |
| Saturday, August 5th, 1978 | | Placed 1B Derrick Young on the 15-day disabled list. |
| Thursday, June 22nd, 1978 | | Activated 2B Lee Flannery from the disabled list. |
| Saturday, June 17th, 1978 | | Placed 3B Jeff Rice on the 15-day disabled list. |
| Thursday, June 15th, 1978 | | Promoted SP Carlos Palmeiro to Double A Tulsa. | | Promoted SS Gerald Cummings to Double A Tulsa. | | Drafted 3B Pat Walker in the 1978 first-year player draft (Round 6, Pick 18, 123rd overall pick). | | Drafted C Arnie Wilson in the 1978 first-year player draft (Round 7, Pick 18, 143rd overall pick). | | Drafted SP Víctor Santos in the 1978 first-year player draft (Round 8, Pick 18, 163rd overall pick). | | Drafted C Juan Acevedo in the 1978 first-year player draft (Round 9, Pick 18, 183rd overall pick). | | Drafted SP Sergio Álvarez in the 1978 first-year player draft (Round 10, Pick 18, 203rd overall pick). |
| Saturday, June 10th, 1978 | | Activated C Ralph Cobb from the disabled list. |
| Tuesday, May 30th, 1978 | | Placed 2B Lee Flannery on the 15-day disabled list. |
| Friday, May 26th, 1978 | | Placed C Ralph Cobb on the 15-day disabled list. |
| Tuesday, April 18th, 1978 | | Placed SS Jesús Díaz on the 15-day disabled list. |
| Monday, January 16th, 1978 | | Activated MR John Bader from the disabled list. |
| Thursday, August 25th, 1977 | | Signed Pitching Coach Johnny McFarland to a 3-year contract extension. | | Signed Hitting Coach Valentín Pérez to a 1-year contract extension. |
|
|
