| | | Wednesday, August 9th, 1978 | | Activated 2B Lester O'Brien from the disabled list. |
| Monday, July 24th, 1978 | | Placed 2B Lester O'Brien on the 15-day disabled list. |
| Saturday, July 1st, 1978 | | Placed 3B Carroll McCain on the 15-day disabled list. |
| Thursday, June 15th, 1978 | | Drafted C Jorge Miranda in the 1978 first-year player draft (Round 6, Pick 5, 110th overall pick). | | Drafted SP Michael Rhodes in the 1978 first-year player draft (Round 7, Pick 5, 130th overall pick). | | Drafted 3B Ricardo Deleón in the 1978 first-year player draft (Round 8, Pick 5, 150th overall pick). | | Drafted CL Kerry Johnson in the 1978 first-year player draft (Round 9, Pick 5, 170th overall pick). | | Drafted SP Ronnie Bishop in the 1978 first-year player draft (Round 10, Pick 5, 190th overall pick). | | Promoted C Jorge Miranda to Double A San Antonio. | | Received 2B Frank McMahon from Double A San Antonio. |
| Tuesday, May 23rd, 1978 | | Placed SP Salvador García on the 15-day disabled list. |
| Thursday, May 4th, 1978 | | Placed SP Dave Meredith on the 15-day disabled list. |
| Tuesday, May 2nd, 1978 | | Activated 1B Brad Rodgers from the disabled list. |
| Thursday, April 27th, 1978 | | Placed MR Gerardo Alvarado on the 15-day disabled list. |
| Thursday, April 13th, 1978 | | Released RF Harley Wright.(Career-ending injury) | | Placed 1B Brad Rodgers on the 15-day disabled list. |
| Sunday, March 26th, 1978 | | Placed MR Brandon González on the 15-day disabled list. |
| Saturday, September 17th, 1977 | | Activated RF Enrique Ríos from the disabled list. |
| Friday, September 16th, 1977 | | Activated SP Octávio López from the disabled list. |
| Tuesday, August 30th, 1977 | | Activated 2B Jarred Roberts from the disabled list. |
| Thursday, August 25th, 1977 | | Released MR Dave Kidd. |
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