| | | Tuesday, June 15th, 1965 | | Promoted 3B Norberto López to Double A San Antonio. | | Promoted 1B César Silva to Double A San Antonio. | | Received C Dale Parker from Double A San Antonio. | | Received 3B Norberto López from Double A San Antonio. | | Drafted 3B Edgardo Delgado in the 1965 first-year player draft (Round 7, Pick 5, 126th overall pick). | | Drafted 1B Aaron Priest in the 1965 first-year player draft (Round 8, Pick 5, 144th overall pick). | | Drafted SP Rafael Ortíz in the 1965 first-year player draft (Round 9, Pick 5, 162nd overall pick). | | Drafted 1B Fletcher Mason in the 1965 first-year player draft (Round 10, Pick 5, 180th overall pick). | | Promoted SP Christian Calvert to Double A San Antonio. | | Received MR Rodrigo Esquire from Double A San Antonio. |
| Tuesday, May 25th, 1965 | | Activated RF Thomas Howe from the disabled list. |
| Monday, May 24th, 1965 | | Activated C Ángel Acevedo from the disabled list. |
| Thursday, May 20th, 1965 | | Activated CF Chris Krieger from the disabled list. |
| Wednesday, May 5th, 1965 | | Activated LF Bill Honrigan from the disabled list. |
| Tuesday, April 20th, 1965 | | Placed LF Bill Honrigan on the 15-day disabled list. |
| Monday, September 21st, 1964 | | Activated C Ron Childress from the disabled list. |
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