| | | Monday, July 31st, 1978 | | Activated SS Mark Conner from the disabled list. |
| Sunday, July 16th, 1978 | | Placed SS Mark Conner on the 15-day disabled list. |
| Sunday, July 9th, 1978 | | Activated 2B William Smith from the disabled list. |
| Thursday, June 15th, 1978 | | Drafted MR Larry Coney in the 1978 first-year player draft (Round 6, Pick 20, 125th overall pick). | | Drafted 1B Errol Moore in the 1978 first-year player draft (Round 7, Pick 20, 145th overall pick). | | Drafted MR Vincente Ochoa in the 1978 first-year player draft (Round 8, Pick 20, 165th overall pick). | | Drafted CF Mike Hollis in the 1978 first-year player draft (Round 9, Pick 20, 185th overall pick). | | Drafted CL Gregory Wood in the 1978 first-year player draft (Round 10, Pick 20, 205th overall pick). | | Promoted 3B Bernardo Sandoval to Double A Laredo. | | Received C Holden O'Bryan from Double A Laredo. |
| Monday, June 5th, 1978 | | Activated RF Oscar House from the disabled list. |
| Tuesday, May 30th, 1978 | | Placed 2B William Smith on the 15-day disabled list. |
| Sunday, April 30th, 1978 | | Placed RF Oscar House on the 15-day disabled list. |
| Thursday, April 20th, 1978 | | Placed 3B Brenton Griffin on the 15-day disabled list. |
| Sunday, December 4th, 1977 | | Activated C Enrico Burgos from the disabled list. | | Activated CF Júlio Mora from the disabled list. |
| Thursday, November 17th, 1977 | | Activated SP Mario Parra from the disabled list. |
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