| Tuesday, August 9th, 1966 | Placed 2B Gabriel Salazar on the 15-day disabled list. | Saturday, July 30th, 1966 | Placed SP Luis Rivera on the 15-day disabled list. | Monday, June 20th, 1966 | Released SS José Crus. | Sunday, June 19th, 1966 | Placed 1B Pablo Ramos on the 15-day disabled list. | Wednesday, June 15th, 1966 | Promoted SP Michael Huff to Double A Laredo. | Promoted SP Bryce Cox to Double A Laredo. | Promoted RF Eduardo Gómez to Double A Laredo. | Received SP Bill Tucker from Double A Laredo. | Received LF Ernest Murdoch from Double A Laredo. | Drafted SP José Rivera in the 1966 first-year player draft (Round 6, Pick 11, 104th overall pick). | Drafted CF Maurice Lyons in the 1966 first-year player draft (Round 7, Pick 11, 122nd overall pick). | Drafted SP Luis Solíz in the 1966 first-year player draft (Round 8, Pick 11, 140th overall pick). | Drafted LF Desi Perry in the 1966 first-year player draft (Round 9, Pick 11, 158th overall pick). | Drafted SP Brian Robinson in the 1966 first-year player draft (Round 10, Pick 11, 176th overall pick). | Tuesday, May 31st, 1966 | Placed RF José Sánchez on the 15-day disabled list. | Wednesday, October 13th, 1965 | MA Greg Boone retires. | 3B Lorenzo Peña becomes a free-agent. | Tuesday, October 12th, 1965 | Activated MR António Parra from the disabled list. | Saturday, October 2nd, 1965 | Activated MR Chuck Sullivan from the disabled list. | Friday, September 17th, 1965 | Placed MR Chuck Sullivan on the 15-day disabled list. | Monday, August 30th, 1965 | Signed manager Greg Boone. | |
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