| | | Sunday, August 6th, 1978 | | Placed LF Clint Nelson on the 15-day disabled list. |
| Thursday, August 3rd, 1978 | | Activated MR John Green from the disabled list. |
| Wednesday, July 19th, 1978 | | Placed MR John Green on the 15-day disabled list. |
| Monday, July 17th, 1978 | | Activated SP Carlin Chambers from the disabled list. |
| Sunday, July 16th, 1978 | | Placed MR Joe Lowery on the 15-day disabled list. |
| Tuesday, July 4th, 1978 | | Placed SP Bob Anthony on the 15-day disabled list. |
| Sunday, July 2nd, 1978 | | Placed SP Carlin Chambers on the 15-day disabled list. |
| Monday, June 26th, 1978 | | Activated LF Carlos Miller from the disabled list. |
| Wednesday, June 21st, 1978 | | Activated 3B Javier Benavidez from the disabled list. |
| Thursday, June 15th, 1978 | | Promoted SS Glenn Stark to Double A Beeville. | | Received C Manny Aranceta from Double A Beeville. | | Received RF Aurelio Barajas from Double A Beeville. | | Drafted CF Luis Cuellar in the 1978 first-year player draft (Round 6, Pick 3, 108th overall pick). | | Drafted CF José Ibarra in the 1978 first-year player draft (Round 7, Pick 3, 128th overall pick). | | Drafted CF Kade Payne in the 1978 first-year player draft (Round 8, Pick 3, 148th overall pick). | | Drafted 2B Roland Weeks in the 1978 first-year player draft (Round 9, Pick 3, 168th overall pick). | | Drafted SP Joe Lowery in the 1978 first-year player draft (Round 10, Pick 3, 188th overall pick). |
| Thursday, May 25th, 1978 | | Activated SS Raúl Guzmán from the disabled list. |
| Friday, May 19th, 1978 | | Activated 2B Jorge Ramírez from the disabled list. |
| Wednesday, May 10th, 1978 | | Placed SS Raúl Guzmán on the 15-day disabled list. |
| Thursday, May 4th, 1978 | | Placed 2B Jorge Ramírez on the 15-day disabled list. |
| Wednesday, May 3rd, 1978 | | Placed LF Greg Turner on the 15-day disabled list. |
| Saturday, August 27th, 1977 | | Activated 2B Clay Labelle from the disabled list. |
| Friday, August 26th, 1977 | | Activated MR Joe Phillips from the disabled list. |
| Thursday, August 25th, 1977 | | Signed Pitching Coach José Matos to a 1-year contract extension. |
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