| Thursday, September 4th, 1980 | Promoted 1B Xiong Tsou to Major League Level Boston. | Tuesday, September 2nd, 1980 | Activated 3B Charlie Jordan from the disabled list. | Tuesday, August 26th, 1980 | Placed LF Manny Adkins on the 15-day disabled list. | Thursday, August 7th, 1980 | Activated CF Cecil Johnston from the disabled list. | Wednesday, July 23rd, 1980 | Placed CF Cecil Johnston on the 15-day disabled list. | Placed 2B Xiong Tsou on the 15-day disabled list. | Wednesday, July 16th, 1980 | Placed LF Kevin Mitchell on the 15-day disabled list. | Wednesday, July 9th, 1980 | Placed C Esteban Fríaz on the 15-day disabled list. | Thursday, July 3rd, 1980 | Activated SP Dani Muńóz from the disabled list. | Wednesday, June 25th, 1980 | Activated C Esteban Fríaz from the disabled list. | Tuesday, June 10th, 1980 | Placed C Esteban Fríaz on the 15-day disabled list. | Sunday, June 8th, 1980 | Placed SP Dani Muńóz on the 15-day disabled list. | Friday, May 9th, 1980 | Activated LF Lévy Gauthier from the disabled list. | Saturday, April 26th, 1980 | Promoted RF Rob Clay to Major League Level Boston. | Wednesday, April 23rd, 1980 | Placed LF Lévy Gauthier on the 15-day disabled list. | |
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